To assess the effectiveness of Aminophylline therapy in a patient with asthma, which data is vital?

• A. Evaluate Theophylline level
• B. Determine the PD50
• C. Recommend a V/Q scan
• D. Perform a bronchoscopy

Answer: (A)

Evaluating the Theophylline level is essential when assessing the effectiveness of Aminophylline therapy in a patient with asthma because Aminophylline is a prodrug that is converted to Theophylline in the body. The therapeutic range of Theophylline is well-established, and monitoring its serum concentration allows healthcare providers to assess whether the patient is receiving an effective dose that achieves the desired bronchodilation while minimizing the risk of toxicity. This information is crucial for adjusting the dosage and ensuring the patient's safety and effectiveness of the treatment.

In contrast, the other options do not provide direct or relevant measurements for evaluating the effectiveness of Aminophylline therapy in this context. The PD50, which refers to the dose required to eliminate 50% of a given endpoint or effect, is not routinely used in clinical practice for this purpose. A V/Q scan is typically utilized to assess ventilation-perfusion mismatch in the lungs but does not directly relate to the efficacy of medication like Aminophylline. Lastly, while bronchoscopy can be useful in evaluating airway conditions, it does not provide information on the pharmacological effectiveness of Aminophylline therapy.